Fos expression in the brains of rats performing an attentional set-shifting task
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منابع مشابه
Fos expression in the brains of rats performing an attentional set-shifting task
Impairments in executive function and cognitive control are a common feature of neuropsychiatric and neurodegenerative disorders. A promising behavioral paradigm for elucidating the neural mechanisms of executive function is extradimensional/intradimensional (ED/ID) shifting, which places demands on executive function by requiring the adjustment of behavioral responses based on affective or att...
متن کاملSensitive to Medial Frontal Cortex Damage in Young Rats Aged Rats Are Impaired on an Attentional Set-Shifting Task
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متن کاملAged rats are impaired on an attentional set-shifting task sensitive to medial frontal cortex damage in young rats.
Normal aging is associated with disruption of neural systems that subserve different aspects of cognitive function, particularly in the hippocampus and frontal cortex. Abnormalities in hippocampal function have been well investigated in rodent models of aging, but studies of frontal cortex function in aged rodents are few. We tested young (4-5 mo old) and aged (27-28 mo old) male Long-Evans rat...
متن کاملExperimental sleep fragmentation impairs attentional set-shifting in rats.
STUDY OBJECTIVE To evaluate the effect of experimental sleep fragmentation (sleep interruption; SI) on complex learning in an intradimensional-extradimensional (ID/ED) set-shifting task in rats. DESIGN A sleep fragmentation paradigm of intermittent forced locomotion was validated in adult rats by examining electrographic effects. Discrimination task performances were assessed in rats followin...
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Adolescent rats show immaturities in executive function and are less able than adult rats to learn reinforcement reversals and shift attentional set. These two forms of executive function rely on the functional integrity of the orbitofrontal and prelimbic cortices respectively. Drugs used to treat attention deficit disorder, such as atomoxetine, that increase cortical catecholamine levels impro...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2010
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2010.09.008